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. 2017 Nov 1;7:14833. doi: 10.1038/s41598-017-12512-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A proposed model of SCARA5 functions in the commitment of mesenchymal stem cells to the adipocyte lineage. In the mesenchymal lineage commitment, dexamethasone induces the expression of SCARA5 through a functional GRE on the promoter. SCARA5 then inactivates FAK signaling, which is reportedly essential for osteogenic differentiation. Through the inactivation of FAK, SCARA5 shifts the fate of mesenchymal stem cells to adipocyte lineage commitment, leading to adipocyte differentiation.