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. 2017 Nov 1;7:14876. doi: 10.1038/s41598-017-13974-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TUDCA treatment increases IDE expression, but not activity in HFD mice. Protein expression of IDE in the liver and its representative immunoblotting images (A). Kinetic of IDE activity assay (B) and total IDE activity (C) in the liver of mice. Fluorescent intensity at Ex/Em = 490/520 nm was recorded, every 5 min, during 60 min. 5-FAM concentration was calculated using a standard curve and normalized per μg of total protein. Mice were fed a control diet (CON) or high fat diet (HFD and HFD + TUDCA) for 12 weeks, and received or not i.p. 300 mg/kg TUDCA during 15 days, as indicated. Data are mean ± SEM (n = 4–8). Data are mean ± SEM (n = 4–8). *P ≤ 0.05 vs CON.