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. 2017 Nov 1;7:14836. doi: 10.1038/s41598-017-13865-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The time evolution of the macropinosome dynamic fingerprint. (A) Exemplary iMSD plots of macropinosomes at three different stages of trafficking: early (30–70 min), intermediate (80–120 min), and late (>130 min). (B) 3D plot showing the time evolution of the dynamic fingerprint of macropinosomes from early (light green) to intermediate (white) and finally late (dark green) stages of trafficking. (C) Statistics on the average size (offset, σ²) of macropinosomes observed at the different time points. (D) Statistics on the average number (N) of macropinosomes observed at the different time points.