Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 1;7:14871. doi: 10.1038/s41598-017-14072-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The roles of Akt1 and Akt2 in the protective effects of HCH in experiment 1. Mice were sacrificed after 4 h of reperfusion and the hearts were harvested for biochemical examinations (n = 56). The protein expression of p-Akt1 (Ser 473), Akt1, p-Akt2 (Ser 474), Akt2, p-Akt (Ser 473), p-Akt (Thr 308), p-Akt (Thr 450), Akt, p-GSK-3β, GSK-3β, e-NOS, Fas, NF-κB p65, pro-caspase-3, and cleaved caspase-3 was detected by western blotting (A,C,E). p-Akt1 expression increased markedly in the heart after 90-min HCH treatment. However, it was reduced significantly in the I/R + HCH + A group (B). There was no significant difference in p-Akt2 (Ser 474) among the I/R, I/R + HCH, I/R + HCH + A, and I/R + A groups, but p-Akt2 (Ser 474) levels were significantly decreased in the I/R + HCH + C and I/R + C groups (D). *P < 0.05 vs. sham; ^# P < 0.05 vs. I/R; ^§ P < 0.05 vs. I/R + HCH; ^≡ P < 0.05 vs. sham; ^‖ P < 0.05 vs. I/R; ^& P < 0.05 vs. I/R + HCH.