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. 2017 Nov 1;7:14829. doi: 10.1038/s41598-017-13675-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of TTNtv mutations in human heart muscle. Clinical and genetic data on the heart muscle samples and location of mutations in the titin molecule, based on the model of Linke and Hamdani²⁹. D6 and D7 have the same mutation but there is no evidence of their relationship except for common ethnicity. The calculated MW of TTNtv are 2611 kDa for D6/D7, 2102 kDa for D9, 125 kDa for D13, 2353 kDa for D23 and 2539 kDa for D28. Abbreviations: NA, not applicable; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; CO, cardiac output; CI, cardiac index; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; FS, fractional shortening; CD, cardiomyopathy; CAD, coronary artery disease; IHD, Ischaemic heart disease; LV, left ventricle; RV, right ventricle; IDCM, idiopathic cardiomyopathy.