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. 2017 Nov 1;7:14829. doi: 10.1038/s41598-017-13675-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Titin isoform expression. (A) 2% agarose/2% polyacrylamide-SDS gel electrophoresis of human heart myofibrils showing separation of titin isoforms, identified in the scanned profile: Two donors, KN1, NK, two failing heart, KF1, KF4, and two TTNtv mutant samples are shown. (B) Comparison of N2BA/N2B ratio measured in donors, TTNtv, other fDCM and idiopathic DCM. Pooled data from multiple gels similar to A. Data shown for donor heart represents KN1 (17 replicates), NK (13 replicates) and NH (8 replicates). Data shown for TTNtv represents D6 (7 replicates), D7 (8 replicates), D9 (6 replicates), D23 (15 replicates), D28 (15 replicates) and D29 (4 replicates). Data for other fDCM represents D1 (5 replicates), D2 (8 replicates), D4 (4 replicates), D11 (9 replicates), D12 (9 replicates) and D15 (9 replicates). Data shown for idiopathic failing heart represents FG (13 replicates), FH (11 replicates), FI (7 replicates), KF1 (8 replicates), KF2 (3 replicates), KF3 (9 replicates) and KF4 (12 replicates). Only idiopathic DCM samples have a significantly higher N2BA/N2B ratio than donor (1.9x).