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. 2017 Nov 1;7:14847. doi: 10.1038/s41598-017-14840-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dynamics of the flickering gate. (a) The three-dimensional structure of the flickering gate is composed by T1, L1, and H3 structural elements. Its closed (blue) and opened (red) states show considerable differences at T1 and L1 conformations. EN is represented with blue (ABS-bound) and red (unbound) sticks. (b) The absence of EN (sticks with green cartoon) from the CBS (grey cloud) results in the breakage of N407 and S329 in the opened state, releasing L1. (c) Consequently, L1 will not maintain its conformation necessary for the interactions with EN, which will readily leave ABS. (b,c) All atom coloring is used for sticks of EN and target residues (grey carbon). Red dotted lines highlight H-bonds, and hydrophobic interactions. Interactions present in the closed state, and absent in the opened state, are marked with red cross.