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. 2017 Nov 1;7:14873. doi: 10.1038/s41598-017-14115-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Change in amplitude contrast vs. ROI size along the depth axis, of sample A. Left panels show the amplitude variance (a) and contrast (b) for a ROI window that is enlarged in size in depth, starting at 0.03 mm optical path length below the cuvette-sample interface. ROI width was ~3.5 mm. In the right panel: amplitude histograms of four specific window sizes (0.08 mm, 0.18 mm, 0.36 mm, 0.50 mm optical path length).