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. 2017 Nov 1;8:1231. doi: 10.1038/s41467-017-01174-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Subclonal evolution of four breast cancers over 2–15 years. a–d Subclonal evolution of breast cancer patients #1 to #4 through treatment. Left side shows variant allele frequencies of copy-neutral somatic SNVs and indels (WGS) organized into clusters, with relevant cancer-associated mutations (may or may not be copy-neutral and includes structural variants) indicated. Right shows subclone evolution. Subclones are indicated by large circles; mutation clusters are indicated by small colored circles. Relevant mutations in subclones are indicated by text or boxed insets. CCF is indicated as percent next to subclone. Filled squares indicate timepoints sequenced by whole-genome sequencing (WGS), filled inverted triangles indicate whole-exome sequencing (WES), and empty squares indicate targeted single-cell DNA sequencing (scDNA). Abr, Abraxane; cap, capecitabine; cb, carboplatin; dox, doxorubicin; erib, eribulin; exem, exemestane; fulv, fulvestrant; gem, gemcitabine; Tax, paclitaxel; trast, trastuzumab; vinorel, vinorelbine. *Patient #3 day 0 had RNA-Seq only. gBRCA2 indicates a germline BRCA2 mutation