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. 2017 Nov 1;8:1231. doi: 10.1038/s41467-017-01174-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — SNV, structural variant, and CNA evolution in four breast cancers. a–d Circos plots showing mutation evolution of breast cancer patients #1 to #4 through treatment. Each circle represents chromosomes 1 through X (clockwise from top) arranged in a circle. Protein-coding somatic SNVs and indels are indicated outside each circle as ticks or, for Cancer Gene Census genes, by name. Germline BRCA2 mutations are indicated as “gBRCA2.” Structural variants (large deletions, translocations, inversions, and duplications) are indicated inside each circle as a line joining the start and end of the variant, with Cancer Gene Census gene mutations indicated outside. Copy number changes are represented in the gray region with higher copy towards the outer edge. Newly appearing SNVs, indels, and structural variants are shown in color, while selected newly appearing CNAs are indicated by colored arrows. CNAs were not determined in the patient #4 day 0 sample due to technical issues with FFPE samples