Fig. 4.

Mutation signature evolution in four breast cancers. a Heatmap showing percent of SNVs in indicated subclones, defined in Fig. 2, with each of 96 possible mutation/trinucleotide context combinations. b Mutation signature weights for COSMIC mutation signatures in indicated subclones. Signatures with <0.03 average weight and mutations not accounted for by known signatures are included in the unknown/other group