Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 31;7:14707. doi: 10.1038/s41598-017-14408-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Doxycycline improves serum biochemical profiles in db/db mice. After food and water fasting for a minimum of 10 h, mice were anesthetized by intraperitoneal injection of pentobarbital (100 mg/kg body weight) before blood samples collection. Serum parameters were determined using an automatic Unicel DxC 800 Chemistry Analyzer (Beckman Coulter, Brea, CA) with respective reagents (Beckman Coulter) in the First Affiliated Hospital of Shantou University for (A) Total cholesterol (TC), (B) triglyceride (TG), (C) HDL-cholesterol, (D) LDL-cholesterol, (E) fasting blood glucose (FBG), (F) insulin (FSI), (G) The homeostasis model assessment-insulin resistance (HOMA-IR) index was calculated using the following equation: HOMA-IR = FSI (mU/L) x FSG (mm)/22.4, (H) Serum levels of AGEs were determined by ELISA. *p < 0.05, **p < 0.01, ***p < 0.001. n = 10.