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. 2017 Oct 31;7:14707. doi: 10.1038/s41598-017-14408-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Doxycycline reduced islet size but increase islet number in db/db mice. (A) H&E staining was carried out on pancreases from each group of mice; Scale bar = 100 μm. (B) The relative islet mass (area) was determined using the Image-Pro Plus 6.0 software, (C) islet number was counted manually, and (D) islet size (area) was calculated by dividing islet area by islet number. Six pancreases from each group of mice were used for the quantification of islet mass, size and number. *p < 0.05, **p < 0.01.