Table 3.
Significant findings of functional annotation cluster analysis for LGDstrict genes with a nominal P < 0.05.
| Category | Term | Count | % | Genes | Fold enrichment | P | Bonferroni |
|---|---|---|---|---|---|---|---|
| GOTERM_BP_FAT | GO:0048484~enteric nervous system development | 2 | 15.4 | RET, TLX2 | 450.93 | 3.99E-03 | 0.564 |
| GOTERM_BP_FAT | GO:0006006~glucose metabolic process | 3 | 23.1 | PHKB, ENO3, AGL | 26.53 | 4.34E-03 | 0.596 |
| GOTERM_BP_FAT | GO:0048729~tissue morphogenesis | 3 | 23.1 | RET, ZEB2, TLX2 | 22.55 | 5.96E-03 | 0.712 |
| GOTERM_BP_FAT | GO:0019318~hexose metabolic process | 3 | 23.1 | PHKB, ENO3, AGL | 21.14 | 6.76E-03 | 0.756 |
| GOTERM_BP_FAT | GO:0005996~monosaccharide metabolic process | 3 | 23.1 | PHKB, ENO3, AGL | 18.28 | 8.95E-03 | 0.846 |
| GOTERM_BP_FAT | GO:0048483~autonomic nervous system development | 2 | 15.4 | RET, TLX2 | 142.40 | 1.26E-02 | 0.928 |
| GOTERM_BP_FAT | GO:0001755~neural crest cell migration | 2 | 15.4 | RET, ZEB2 | 117.63 | 1.52E-02 | 0.959 |
| GOTERM_BP_FAT | GO:0048598~embryonic morphogenesis | 3 | 23.1 | RET, ZEB2, TLX2 | 13.22 | 1.66E-02 | 0.969 |
| GOTERM_BP_FAT | GO:0006091~generation of precursor metabolites and energy | 3 | 23.1 | PHKB, ENO3, AGL | 12.97 | 1.73E-02 | 0.973 |
| GOTERM_BP_FAT | GO:0014033~neural crest cell differentiation | 2 | 15.4 | RET, ZEB2 | 81.99 | 2.17E-02 | 0.990 |
| GOTERM_BP_FAT | GO:0014032~neural crest cell development | 2 | 15.4 | RET, ZEB2 | 81.99 | 2.17E-02 | 0.990 |
| GOTERM_BP_FAT | GO:0005977~glycogen metabolic process | 2 | 15.4 | PHKB, AGL | 77.30 | 2.31E-02 | 0.992 |
| GOTERM_BP_FAT | GO:0006073~cellular glucan metabolic process | 2 | 15.4 | PHKB, AGL | 75.16 | 2.37E-02 | 0.993 |
| GOTERM_BP_FAT | GO:0044042~glucan metabolic process | 2 | 15.4 | PHKB, AGL | 75.16 | 2.37E-02 | 0.993 |
| GOTERM_BP_FAT | GO:0001667~ameboidal cell migration | 2 | 15.4 | RET, ZEB2 | 73.12 | 2.44E-02 | 0.994 |
| GOTERM_BP_FAT | GO:0006112~energy reserve metabolic process | 2 | 15.4 | PHKB, AGL | 62.92 | 2.83E-02 | 0.997 |
| GOTERM_BP_FAT | GO:0001838~embryonic epithelial tube formation | 2 | 15.4 | RET, ZEB2 | 62.92 | 2.83E-02 | 0.997 |
| GOTERM_BP_FAT | GO:0035148~tube lumen formation | 2 | 15.4 | RET, ZEB2 | 61.49 | 2.89E-02 | 0.998 |
| GOTERM_BP_FAT | GO:0048762~mesenchymal cell differentiation | 2 | 15.4 | RET, ZEB2 | 53.05 | 3.34E-02 | 0.999 |
| GOTERM_BP_FAT | GO:0014031~mesenchymal cell development | 2 | 15.4 | RET, ZEB2 | 53.05 | 3.34E-02 | 0.999 |
| GOTERM_BP_FAT | GO:0060485~mesenchyme development | 2 | 15.4 | RET, ZEB2 | 52.03 | 3.41E-02 | 0.999 |
| GOTERM_BP_FAT | GO:0044264~cellular polysaccharide metabolic process | 2 | 15.4 | PHKB, AGL | 51.05 | 3.47E-02 | 0.999 |
| GOTERM_BP_FAT | GO:0016331~morphogenesis of embryonic epithelium | 2 | 15.4 | RET, ZEB2 | 46.65 | 3.79E-02 | 1.000 |
| GOTERM_BP_FAT | GO:0060562~epithelial tube morphogenesis | 2 | 15.4 | RET, ZEB2 | 40.38 | 4.37E-02 | 1.000 |