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. 2017 Sep 14;108(11):2248–2264. doi: 10.1111/cas.13354

Figure 8.

Figure 8

Solasodine regulates the AKT/glycogen synthase kinase‐3β (GSK‐3β)/β‐catenin signaling and restrains nuclear translocation of β‐catenin. (a) RT–quantitative PCR analysis was carried out to test mRNA expression of AKT/GSK‐3β/β‐catenin elements. (b,c) Western blot analysis of AKT/GSK‐3β/β‐catenin‐related proteins. Data are shown as the mean ± SD. *P < 0.05, **P < 0.01 versus control group. (d) Immunofluorescence staining analysis of cytoplasmic and nuclear expression of β‐catenin. Magnification, ×200.5‐Fu, 5‐fluorouracil; mTOR, mammalian target of rapamycin.