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Solasodine induces apoptosis and prohibits AKT/glycogen synthase kinase‐3β (GSK‐3β)/β‐catenin signaling in HCT116 xenograft tumors. Tumors were abscised after the last solasodine i.p. injection and mRNA or protein was extracted. (a–c) RT–quantitative PCR and Western blot studies were undertaken to evaluate the levels of AKT/GSK‐3β/β‐catenin, apoptotic, and invasive molecules. 5‐Fu, 5‐fluorouracil; PARP, poly (ADP‐ribose) polymerase.
