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. 2017 Oct 15;9(10):4402–4414.

Figure 2.

Figure 2

The effects of miR-665 on VSMCs proliferation, invasion and migration. A and B. The expression level of miR-665 in VSMCs was measured by qRT-PCR assay 48 h after cells transfected with miR-665 mimics, miR-665 inhibitor, or their respective controls. MiR-665 mimics transfection increased the miR-665 expression, and miR-665 inhibitor transfection suppressed the miR-665 expression level. C and D. The VSMCs proliferation was measured by CCK-8 assay 48 h after cells transfected with miR-665 mimics, miR-665 inhibitor, or their respective controls. MiR-665 mimics transfection increased VSMCs proliferation, and miR-665 inhibitor transfection suppressed the VSMCs proliferation. E and F. The VSMCs invasion was measured by transwell assay 48 h after cells transfected with miR-665 mimics, miR-665 inhibitor or their respective controls. MiR-665 mimics transfection increased VSMCs invasion, and miR-665 inhibitor transfection suppressed VSMCs invasion. G and H. The VSMCs migration was measured by wound healing assay 48 h after cells transfected with miR-665 mimics, miR-665 inhibitor, or their respective controls. MiR-665mimics transfection enhanced VSMCs migration, and miR-665 inhibitor transfection suppressed VSMCs migration. Data represents the mean values of three independent replicates ± SEM; significant differences relative to control group were shown as *P<0.05, ***P<0.001.