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Schematic illustration demonstrating the role of miR-665 in VSMCs. PDGF-bb or 20% serum treatment suppressed miR-665 expression. MiR-665 inhibited Wnt/β-catenin signaling activities possibly via suppressing FGF9 or MEF2D or by other unidentified mechanism, and the inhibition of FGF9, MEF2D and the activities of Wnt/β-catenin signaling may contribute to the suppression of VSMCs proliferation.
