Table 3.
Target genes of miR-25 and their function in relation to tumorigenesis
| miRNA | Target gene | Description | Validated or not |
|---|---|---|---|
| miR-25 | DSC2 | Intercellular desmosome junction | YES |
| CDH1 | Tumor metastasis suppressor | YES | |
| RECK | Reversed oncogenic effect | YES | |
| E2F1 | A transcription factors | YES | |
| MOAP1 | Involved in regulation of cell apoptosis | YES | |
| TOB1 | An anti-proliferative protein | YES | |
| BTG2 | YES | ||
| CDC42 | A member of Rho GTPase family | YES | |
| β-TRCP2 | A ubiquitin ligase | YES | |
| RGS3 | Regulator of G protein signaling 3 | YES | |
| EP300 | A transcriptional activator of E-cadherin | YES | |
| PTEN | A tumor suppressor | YES | |
| LATS2 | YES | ||
| FBXW7 | YES | ||
| TSC1 | NO | ||
| Smad7 | Antagonist of signaling by TGF-beta | YES | |
| Bim | A pro-apoptotic protein | YES | |
| SYT1 | Tumor suppressor gene involved in the synaptic activity regulation | NO | |
| MAP2K4 | Dual specificity kinasethat activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) | NO | |
| CUX1 | As a repressor of developmentally regulated gene expression | NO | |
| GPRC5A | Involved in modulating differentiation and maintaining homeostasis of epithelial cells | NO | |
| ZEB2 | A transcriptional inhibitor of E-cadherin | NO | |
| MBD2 | A transcriptional repressor | NO | |
| MDM4 | Inhibit p53- and p73-mediated cell cycle arrest and apoptosis | NO | |
| NEO1 | Involved as a regulatory protein in the cell differentiation | NO | |
| TP63 | Acted as transcriptional activator or repressor | NO |