Table 2.
Frequent copy number alteration regions in colorectal adenomas and intramucosal adenocarcinoma (IMA)
| Chromosomal regions | LGA (n = 35) | Chromosomal regions | HGA (n = 20) | Chromosomal regions | IMA (n = 30) |
|---|---|---|---|---|---|
| Gain | Gain | Gain | |||
| None | 7q11.22-23 | 7 (35.0%) | 13q12.13-12.2, q13.2-13.3 | 18 (60.0%) | |
| CNLOH | 7q11.1-11.21 | 6 (30.0%) | 13q31.1-32.1, q33.2-3 | 17 (56.7%) | |
| None | 7q21.11-36.3 | 6 (30.0%) | 13q21.1-22.1 | 17 (56.7%) | |
| LOH | 7p11.2-22.3 | 6 (30.0%) | 13q14.11-14.13, q14.3 | 17 (56.7%) | |
| None | 9p13.1 | 6 (30.0%) | 13q12.11-12.12, q12.3-13.1 | 17 (56.7%) | |
| CNLOH | 13q11, q14.2, q22.2-33.1 | 16 (53.3%) | |||
| 5q15-35.3 | 8 (40.0%) | 13q32.2-32.3 | 15 (50.0%) | ||
| 5q14.3 | 7 (35.0%) | 13q34 | 14 (46.7%) | ||
| LOH | 7q11.21, 20q13.33 | 13 (43.3%) | |||
| None | 7p12.3-22.3, 7q11.22-36.3 | 12 (40.0%) | |||
| 8p11.21-11.22 | 12 (40.0%) | ||||
| 20q11.21-13.32 | 12 (40.0%) | ||||
| 7p11.2-12.2, 8q21.11-24.13 | 11 (36.7%) | ||||
| 20q12-13.13 | 11 (36.7%) | ||||
| 18p11.31-32 | 10 (33.3%) | ||||
| 17p12, 18q12.1-12.3 | 9 (30.0%) | ||||
| CNLOH | |||||
| 5q14.1 | 10 (33.3%) | ||||
| 5q14.2-35.3 | 9 (30.0%) | ||||
| LOH | |||||
| None |
CNLOH copy-neutral loss of heterozygosity, HGA high-grade adenoma, LGA low-grade adenoma, LOH loss of heterozygosity