Table 3.
Significant differences in the frequencies of copy number alterations between high-grade colorectal adenoma (HGA) and intramucosal adenocarcinoma (IMA)
| Chromosomal regions | HGA (n = 20) | IMA (n = 30) | P |
|---|---|---|---|
| Gain | |||
| 13q12.13-2, 13q13.2-3 | 0 | 18 (60.0%) | <0.001 |
| 13q12.11-13.1, 13q14.11-14.13 | 0 | 17 (56.7%) | <0.001 |
| 13q11, 13q14.2 | 0 | 16 (53.3%) | <0.001 |
| 13q32.2 | 0 | 15 (50.0%) | <0.001 |
| 13q21.2, 13q22.1, 13q32.1, 13q33.2-3 | 1 (5.0%) | 17 (56.7%) | <0.01 |
| 13q22.2-33.1 | 1 (5.0%) | 16 (53.3%) | <0.01 |
| 13q14.3-21.1, 13q21.31-33, 13q31.1-3 | 2 (10.0%) | 17 (56.7%) | <0.01 |
| 13q32.3 | 1 (5.0%) | 15 (50.0%) | <0.01 |
| 13q34 | 1 (5.0%) | 14 (46.7%) | <0.01 |
| 17p12 | 0 | 9 (30.0%) | 0.02 |
| 17p11.2, 17p13.1-13.2 | 0 | 8 (26.7%) | 0.03 |
| 18p11.31-32 | 1 (5.0%) | 10 (33.3%) | 0.04 |
| CNLOH | |||
| None | |||
| LOH | |||
| None | |||
CNLOH copy-neutral loss of heterozygosity, LOH loss of heterozygosity