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. 2017 Oct 11;7(10):170172. doi: 10.1098/rsob.170172

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© 2017 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — Co-deletion (coDel). A DNA construct in which a non-IES sequence (target) is inserted into the middle of a Type-A IES (i) is introduced into the developing MAC (ii). The Type-A IES of the construct is recognized by Early-scnRNAs that are produced from the corresponding endogenous Type-A IES (iii) and trigger Late-scnRNA production from the adjacent target sequence in cis (iv). Late-scnRNAs then recognize the endogenous target locus in trans (v) and induce ectopic DNA elimination (vi). Yellow circles indicate the hypothetical IRHs.