Table 1.

Baseline Demographics in DCM Patients Stratified by TTNtv Status

	TTNtv Absent (n = 633)	TTNtv Present (n = 83)	p Value
Age at baseline, yrs	54.1 ± 14.3	49.0 ± 13.5	0.002
Male	410 (64.8)	59 (71.1)	0.27
Caucasian	533 (84.2)	75 (90.4)	0.39
Family history of DCM	87 (13.7)	26 (31.3)	<0.001
Family history of sudden cardiac death	95 (15.0)	12 (14.5)	1.0
History of peripartum cardiomyopathy	6 (0.9)	1 (1.2)	0.58
History of chemotherapy	32 (5.1)	2 (2.4)	0.41
History of moderate alcohol excess∗	98 (15.5)	13 (15.7)	1.0
NYHA functional class†			0.17
1	261 (43.1)	39 (49.4)
2	245 (40.4)	32 (40.5)
3	94 (15.5)	6 (7.6)
4	6 (1.0)	2 (2.5)
Hypertension	203 (32.1)	10 (12.0)	<0.001
Diabetes mellitus	79 (12.5)	8 (9.6)	0.57
Beta-blocker use	444 (70.1)	60 (72.3)	0.80
ACE inhibitor or ARB use	503 (79.5)	64 (77.1)	0.67
Aldosterone antagonist use	226 (35.7)	31 (37.3)	0.81
Diuretic use	287 (45.3)	41 (49.4)	0.49
Conduction disease	217 (34.3)	18 (21.7)	0.03
Left bundle branch block	179 (28.5)	8 (9.8)	<0.001
History of atrial fibrillation	140 (22.1)	23 (27.7)	0.27
History of nonsustained ventricular tachycardia	67 (10.6)	16 (19.3)	0.03
History of sustained ventricular tachycardia	14 (2.2)	1 (1.2)	1.0

Age is summarized as mean ± SD and compared with the Mann-Whitney test. The remaining categorical variables are summarized as n (%) and compared using the Fisher exact test.

ACE = angiotensin-converting enzyme; ARB = angiotensin receptor blocker; DCM = dilated cardiomyopathy; NYHA = New York Heart Association; TTNtv = truncating variants in the titin gene.

^∗Patients with a history of alcohol consumption in excess of the U.K. government weekly “sensible limits.” Patients meeting criteria for alcoholic cardiomyopathy were excluded from the cohort.

^†Missing data in 31 patients (4.3%).