Table 1. Baseline parameters of all 222 patients.
| All patients (n=222) | HBeAg positive (n=90) | HBeAg negative (n=132) | P value | |
|---|---|---|---|---|
| Age (years) | 47 (21–77) | 41 (21–66) | 50 (24–77) | <0.01 |
| Number of male | 157 (70.7%) | 65 (72.2%) | 92 (70.0%) | 0.69 |
| HBV DNA (log IU/ml) | 6.4 (3.3–>8.1) | 7.3 (3.3–>8.1) | 6.0 (3.5–>8.1) | <0.01 |
| HBV DNA (≥7.3 log IU/ml) | 71 (32.0%) | 48 (53.3%) | 23 (17.4%) | <0.01 |
| HBsAg (log IU/ml) | 3.41 (0.96–5.88) | 3.95 (0.96–5.88) | 3.36 (0.96–5.50) | <0.01 |
| HBcrAg (log kU/ml) | 2.89 (0.00–7.07) | 4.57 (0.00–7.07) | 2.09 (0.00–6.00) | <0.01 |
| Percentage of patients with undetectable HBcrAg | 7.5% (16/214) | 1.1% (1/87) | 11.8% (15/127) | <0.01 |
| Albumin (g/l) | 42 (22–50) | 42 (22–48) | 42 (22–50) | 0.97 |
| Bilirubin (μmol/l) | 13 (2–216) | 13 (2–67) | 13 (4–216) | 0.68 |
| ALT (U/l) | 92 (17–2,168) | 100 (27–2,144) | 81 (17–2,168) | 0.25 |
| Number of patients with elevated ALT level | 181 (81.5%) | 76 (84.4%) | 105 (79.5%) | 0.36 |
Abbreviations: ALT, alanine aminotransferase; HBcrAg, hepatitis B core-related antigen; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV DNA, hepatitis B virus DNA.
Continuous variables were expressed as median (range).
P values are for the comparisons between HBeAg-positive and -negative patients.