Table 4a. Factors associated with undetectable HBcrAg at the seventh year in all patients: univariate and mulitvariate analysis.
| Undetectable HBcrAg (n=47) | Detectable HBcrAg (n=100) | P value (univaraite) | OR (95% CI) | P value (multivariate) | |
|---|---|---|---|---|---|
| Age (years (mean, 95% CI)) | 50.9 (28.7–70.8) | 46.9 (21.0–66.8) | 0.004 | 1.004 (0.933–1.081)a | 0.906 |
| Sex (M, %) | 37 (78.7%) | 70 (70.0%) | 0.268 | ||
| Raised ALT at baseline (>50 IU/ml) | 38 (80.9%) | 82 (82.0%) | 0.867 | ||
| Negative HBeAg at baseline | 43 (91.5%) | 50 (50.0%) | <0.001 | 11.47 (1.75–75.29) | 0.011 |
| Baseline HBV DNA <7.8 log IU/ml | 43 (91.5%) | 58 (58.0%) | <0.001 | 0.62 (0.12–3.15) | 0.561 |
| Baseline HBsAg <1,000 IU/ml | 20 (42.6%) | 4 (4.0%) | <0.001 | 10.72 (1.65–69.53) | 0.013 |
| Baseline HBcrAg <2 log KU/ml | 24 (51.1%) | 9 (9.0%) | <0.001 | 5.59 (1.60–19.49) | 0.007 |
Abbreviations: ALT, alanine aminotransferase; CI, confidence interval; HBcrAg, hepatitis B core-related antigen; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV DNA, hepatitis B virus DNA.
a
Per unit increase in age.