Table 4b. Factors associated with undetectable HBcrAg at the seventh year in HBeAg-negative patients: univariate and mulitvariate analysis.
| Undetectable HBcrAg (n=43) | Detectable HBcrAg (n=50) | P value (univaraite) | OR (95% CI) | P value (multivariate) | |
|---|---|---|---|---|---|
| Age (years (mean, 95% CI)) | 51.4 (48.8–54.0) | 50.0 (47.6–52.3) | 0.415 | ||
| Sex (M, %) | 33 (76.7%) | 33 (66.0%) | 0.255 | ||
| Raised ALT at baseline (>50 IU/ml) | 34 (79.1%) | 38 (76.0%) | 0.724 | ||
| Baseline HBV DNA <7.8 log IU/ml | 41 (95.3%) | 37 (74.0%) | 0.005 | 1.16 (0.16–8.71) | 0.884 |
| Baseline HBsAg <1,000 IU/ml | 20 (46.5%) | 3 (6.0%) | <0.001 | 13.58 (1.47–125.68) | 0.022 |
| Baseline HBcrAg <2 log KU/ml | 24 (55.8%) | 6 (12.0%) | <0.001 | 6.39 (1.66–24.63) | 0.007 |
Abbreviations: ALT, alanine aminotransferase; CI, confidence interval; HBcrAg, hepatitis B core-related antigen; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV DNA, hepatitis B virus DNA.