Table 2.
Contribution of variables and individual reactions on the principal components. (The variable hypoxia is highly correlated with the first component (PC1), compared to variable HypoxiaAA. This variation is driven by excess amino acids present in HypoxiaAA in addition to the lack of oxygen. The individual reactions on the first two principal components show oxygen transporter (reaction id: Transporter47) and to some extent ATP production (reaction id: BioMass5) scored highly, indicating a significant effect on ATP synthase activity (see text for a more detailed description).)
| condition | PC 1 | PC 2 | PC 3 | |
|---|---|---|---|---|
| (a) | ||||
| normoxia | 0.979 | −0.185 | 0.083 | |
| hypoxia | 0.991 | −0.076 | −0.108 | |
| HypoxiaAA | 0.963 | 0.267 | 0.027 | |
| reaction ID | reaction description | PC 1 | PC 2 | PC 3 |
| (b) | ||||
| Transporter47 | oxygen transporter | 16.486 | 6.859 | 1.170 |
| BioMass5 | ATP production | 17.570 | 0.360 | 0.259 |
| R00086MM | ATP synthase | 13.241 | 0.162 | 1.401 |
| R02161MM | complex III | 0.823 | 1.175 | 0.132 |
| R02163MM | complex I | 1.343 | 1.685 | 0.653 |
| Boundary2 | oxygen uptake | 0.198 | 0.305 | 0.030 |