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. 2017 Sep 19;9(11):1589–1604. doi: 10.15252/emmm.201707814

Figure 1. Gene profiling reveals enhanced carbohydrate uptake and metabolism in tumor cells from HB compared to HCC.

Figure 1

  1. Multidimensional scaling (MDS) plot of the expression levels derived from the RNAseq. Distance between sample labels indicates similarity. Samples form four distinct groups according to the four cell line types.
  2. Heatmap of the enrichment scores from the single‐sample GSEA. Each column of the heatmap shows a cell line, while the rows represent gene sets. The plotted gene sets are the top 50 differentially enriched sets in HCC versus HB cell lines ranked by FDR. Color scale in the heatmap represents scores standardized across rows.
  3. Heatmap of the enrichment scores from the single‐sample GSEA. Each column of the heatmap shows a cell line, while the rows represent gene sets. The plotted gene sets are those that have been found as significantly enriched or depleted in HCC versus HB cell lines at a false discovery ratio (FDR) < 0.05. Differential enrichment is assessed on the ssGSEA enrichment scores with the limma package. Color scale in the heatmap represents scores standardized across rows.
  4. Expression levels from RNAseq of the different glucose transporters differentially expressed in all HB compared to all HCC cell lines. Data show means ± s.d. (n = 4). P‐values were determined by Mann–Whitney test.