Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 3;36(43):6020–6029. doi: 10.1038/onc.2017.207

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

PMC Copyright notice

Blocking steatosis inhibits tumor development in Pten-null livers and alters Wnt signaling. (a) Liver tissue sections were collected from 13-month-old control (Con), Pten-null (Pm) and Pten/Akt2 double null (Pten/Akt2, Dm) mice. Pten-null mice were fed either ad libitum (AL) or calorie restriction (CR) diet. Left, macroscopic images of livers. Right, microscopic images of liver tissue sections showing both hepatocytes and cholangiocytes in the tumor. n=6–11. (b) Wnt signature genes that are differentially expressed in Pten-null (Pm) livers and altered by deletion of Akt2 (double mutant, Dm) and CR. The majority of the Kyoto Encyclopedia of Genes and Genomes (KEGG) Wnt signature genes found altered by Pten deletion were found to be reversed by Akt2 deletion (left) or CR (right). Data collected from microarray analysis of Pm vs Dm (Top) and RNA-seq analysis of Pm Al, vs Pm CR (Bottom). n=3–5.