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. 2017 Jul 3;36(43):6020–6029. doi: 10.1038/onc.2017.207

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Inhibiting steatosis blocks accumulation of TICs. (a) Representative flow cytometric (FACS) plot of TICs in Pten-null (Pm) vs Pten/Akt2 double mutant (Dm) mice using CD49f and CD133 to identify TICs. Left, Representative FACS plot; Right, quantitative analysis. n=4–5. * Significantly different from controls at P⩽0.05. 9-month-old mice. (b) Quantification of FACS analysis of TIC populations in AL (n=6) and CR (n=7)-fed Pten-null mice. * Significantly different from AL at P⩽0.05. 3-month-old animals were put on CR diet for 10 months. (c) Hepatic TIC markers are induced in Pm/AL mice and blocked with CR. n=6–11. a, significantly different from control. b, significantly different from Pm. P⩽0.05.