Figure 2.

A diagram of the FGFR2 mediated signaling pathways. Various FGFs bind to FGFR2b or FGFR2c, respectively, with HSPG as a cofactor and induce the formation of ternary FGFs-FGFR2-HS complex, which activates the FGFR2 intracellular tyrosine kinase domain by phosphorylation of specific tyrosine residues. The activated TK of FGFR2, in turn, triggers activation of multiple downstream signaling pathways, which not only regulate differentiation and gene expression in the nucleus, but also drive cell proliferation and survival as well.