Table 3.

Mutations in FGFR2 identified in diverse human cancers

Human Cancer Disease	Mutations	Ref.
Adenoid cystic carcinoma	K642R, Y376C	109, 112, 113
Bladder cancer	M186T	114
Breast cancer	R203C, N550K, S588C, K660M	68, 109, 112, 115, 116
Cervical cancer	A97T, S252L, P256S, K406E, M585V, Y589D, K660M	68, 117
Colorectal cancer	R203H, R210Q, D334N, Q361R, L552I, P583L, R665W, E778K.	118-120
Endometrial cancer	D101Y, G227E, S252W, P253R, F276V, K310R, S373C, Y376C, C383R, A390T, M393R, V396D, L398M, I548D/V, N550H/K, K660E/M/N, C383R	68, 109, 112, 121
Gallbladder cancer	N550K, S252W	118
Gastric cancer	S267P, Q212K, G463E	120, 122, 123
Head and neck squamous cell cancer	N550D	124
Lung cancer	E116K, P253L, I381V, C383R, K421I, D480N, H545Q, G584V, I591M, Q621K, R626T, D138N, N211I, D247Y, D283N, W290C, G302W, S320C, E471Q, M538I, G584W, D603E, K660N/E, L773F, T787K	102, 125-131
Melanoma	S24F, V77M, H213Y, E219K, G227E, V248D, R251Q, G271E, G305R, T371R, E476K, D531N, E575K, E637K, M641I, I643V, A649T, S689F, G702S, P709S, R760Q, L771V	132
Oral cancer	V393A, G272V, P253R	115, 130
Spermatocytic seminoma	S252F/W, P253R/S, S267P, F276V, C278F, Y281C, Q289P, G336R, Y338C/H, C340F/R/S, S352C, K527E, N550K, K642R, K660E	133