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. 2017 Nov;14(11):1657–1664. doi: 10.1016/j.hrthm.2017.06.012

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© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effect of holding potential (HP) on percentage use-dependent block by ranolazine. A: Mean percentage use-dependent block at diastolic interval (DI) of 110, 60, and 40 ms in atrial (filled columns, n = 6) and ventricular (open columns, n = 5) from an HP of −120 mV. B: Percentage use-dependent block at DI of 110, 60, and 40 ms in atrial (filled columns, n = 6) and ventricular (open columns, n = 6) from an HP of −110 mV. C: Percentage use-dependent block at DI of 110, 60, and 40 ms in atrial (filled columns, n = 5) and ventricular (open columns, n = 9) from an HP of −100 mV. Use-dependent block was significantly different by factorial mixed analysis of variance (P < .001). Data were significantly different by DI (P < .001), HP (P < .001), and cell type (P = .001). There was a significant interaction between cell type and HP (P < .001). In Bonferroni post hoc tests, the effect of 110 ms DI was significantly different from 60 ms (P = .001) and 40 ms (P < .001) but there was no statistical confidence in the difference between DI of 60 ms and 40 ms (P = .146). Similarly, the effect of an HP of −120 mV was significantly different from both −110 mV (P < .001) and −100 mV (P < .001) but the effect of −110 mV was not different from −100 mV (P = 1.000).