Figure 7.

Effect of ranolazine (RAN) on I_Na recovery from inactivation. A: Recovery of I_Na from inactivation in atrial (filled symbols, n = 6) and ventricular (open symbols, n = 5) myocytes. Dashed lines represent fits to Supplemental Equation 4. The holding potential during recovery was −120 mV. B: Fitted fast (left-hand panel) and slow (right-hand panel) time constants in control and in the presence of 30 μM RAN for atrial (filled columns) and ventricular (open columns) myocytes. *P < .05; ***P < .001; 2-way repeated measures analysis of variance (RM ANOVA) with Bonferroni post hoc test vs control. C: Mean amplitude of slow component in control and in the presence of 30 μM RAN for atrial (filled columns) and ventricular (open columns) myocytes. *P < .05; 2-way RM ANOVA with Bonferroni post hoc test vs control.