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Amino acid sequence alignment of different type I RIPs compared to ricin (RTA), abrin and cinnamomin catalytic A chains by T-Coffee. Color shades indicate levels of amino acid homology between the aligned sequences. Conserved amino acids are identified with an asterisk and residues crucial for the catalytic activity are arrowed: Tyr72, Tyr120, Glu176, Arg179 and Trp208 in the sequence of saporin.
