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Three-dimensional reconstruction of catalytic cleft of saporin obtained by Swiss PDB Viewer (v4.0.4, SIB—Swiss Institute of Bioinformatics, Lausanne, Switzerland). Conserved residues crucial for the RIP signature are colored: Tyr72 (yellow), Tyr120 (red), Glu176 (orange), Arg179 (green) and Trp208 (blue). Hydrogen bonds among key residues are shown in orange.
