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. 2017 Oct 13;9(10):321. doi: 10.3390/toxins9100321

Figure 6.

Figure 6

Secretion of MP-V1 to the extracellular space through the Sec-dependent type II secretion system. In the cytosol, the OmpA SS, a signal sequence of the OmpA SS::MP-V1, a translated target protein, is recognized by the SecA protein, which guides it to the plasma membrane, and the random folding of the target protein can be prevented by SecB, a chaperone protein. Subsequently, the OmpA SS fusion protein is translocated to the periplasm through the SecYEG complex in the inner membrane, the OmpA SS signal peptide is digested by the LepB, a peptidase, and then the digested MP-V1 is released freely into the periplasm. Finally, the digested peptide is secreted as the active MP-V1 to the extracellular space through the type II secretion system consisting of the general secretory proteins (GSPs). The left green box summarizes the procedure from the OmpA SS::MP-V1 protein to the active MP-V1.