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Significant amino acids for toxin-induced modulation of TRPV1 activity. (A) The outer pore region is collectively colored in gold, and S1–S4 are labeled in fuchsia. Intracellular structures are blue. PDB ID: 5IRZ. (B) Key amino acids indicated in channel activation by each individual toxin are labeled according to the toxin: DkTx, Red; RhTx, Blue; BmP01, Purple; APHC, Green. Whole subunits are lightly colored to visualize the interface between adjacent subunits. PDB ID: 5IRZ.
