Table 1.
Species | Toxin | ||
---|---|---|---|
Chinese earth tiger tarantula Chilobrachys guangxiensis |
Double-knot toxin (DkTx) [36] | Key Amino Acids |
TRPV1: Y453, R534, K535, E536, I599, S629, Y631, F649, T650, A657, N652, D654, F655, K656, A657, V658, F659 DkTx: K1: W11, G12, K14, and F27 K2: W53, G54, K56 and F67 |
Behavioral effects | Unknown | ||
Potency | EC50 = 0.23 µM | ||
Chinese red-headed centipede Scolopendra subspinipes mutilans |
RhTx [51] | Key Amino Acids |
TRPV1: D602, Y632, T634, Possibly L461 RhTx: D20, K21, Q22, R15, E27 |
Behavioral effects | Acute pain response when injected into mice | ||
Potency | EC50 = 521.5 ± 162.1 nM | ||
Chinese Scorpion Mesobuthus martensii |
BmP01 [59] | Key Amino Acids | TRPV1: E648, T651, E652 |
Behavioral effects | Injection of 500 µM BmP01 evokes a pain response in wt mice but not in TRPV1 KO mice | ||
Potency | EC50(Ph=6.5) = 3.76 ± 0.4 µM EC50(Ph=7.5) = 169.5 ± 12.3 µM |
||
Palestine saw-scaled viper Echis coloratus |
F13 [69] | Key Amino Acids | Unknown |
Behavioral effects | Unknown | ||
Potency | Unknown | ||
Sebae anemone Heteractis crispa |
Heteractis crispa RG 21 (HCRG21) [34] | Key Amino Acids | HCRG21: E6, T14, P31 E38, R48, R51 |
Behavioral effects | Unknown | ||
Potency | IC50 = 6.9 ± 0.4 µM | ||
Analgesic polypeptide Heteractis crispa (APHC1-3) [78] | Key Amino Acids |
TRPV1: D648, E651, Y653, E636, Y627, D646 APHC: V31, R48, R51, R55 |
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Behavioral effects |
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Potency | APHC1: IC50 = 6.9 ± 0.4 µM APHC3: IC50 = 18 nM |