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Human platelets exposed to rCPB are irresponsive to thrombin activation. Platelets were incubated with PBS or rCPB for the indicated times followed by addition of thrombin. While control platelets reacted to thrombin with typical shape change and formation of pseudopodia at all time points, platelets incubated with rCPB (250 ng/mL) showed only slight signs of activation at 5 min and did not display thrombin-induced changes after 15 or 60 min of toxin exposure.
