Table 2.
Effect of 4-week CVM on biochemical assessments of energy metabolism in mice
| Vehicle | CVM-1X | CVM-2X | CVM-5X | Trend analysis | |
|---|---|---|---|---|---|
| CK (U/L) | 132±17b | 90±9a | 99±10a | 86±7a | 0.0353 |
| Glucose (mg/dL) | 193±8b | 187±5ab | 177±6ab | 173±5a | 0.0024 |
| LDH (U/L) | 297±16ab | 302±12ab | 325±13b | 270±13a | 0.3523 |
| T-Chol (mg/dL) | 156±5a | 147±6a | 143±4a | 143±5a | 0.0894 |
| TG (mg/dL) | 103±9b | 87±9b | 51±6a | 51±4a | <0.0001 |
Mice were pretreated with vehicle, CVM-1X, CVM-2X and CVM-5X for 28 days. Vehicle; vehicle control, CVM-1X; 615 mg/kg/day of CVM, CVM-2X; 1230 mg/kg/day of CVM, CVM-5X; 3075 mg/kg/day of CVM. Data are mean±SEM (n = 8 mice/group). Different letters indicated significant difference at p<0.05 by one-way ANOVA. A statistically significant dose-trend was p<0.05 by the SPSS 19.0.