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. 2017 Sep 8;14(11):1143–1153. doi: 10.7150/ijms.21353

Figure 3.

Figure 3

Reduced transcriptional activity of MEF2C caused by the mutation. Activation of the ANF promoter driven luciferase in HeLa cells by wild-type MEF2C or L38P-mutant MEF2C (L38P), alone or together, showed significantly reduced transcriptional activity by the mutant protein. Three independent transfection experiments were conducted in triplicate for each expression plasmid, and mean and standard deviations are shown. ** indicates t = 10.7379, p = 0.00043; * indicates t = 6.29383, p = 0.00326, when compared with wild-type MEF2C (1.0 μg).