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. 2017 Sep 8;14(11):1143–1153. doi: 10.7150/ijms.21353

Figure 4.

Figure 4

Diminished synergistic transcriptional activation between MEF2C and GATA4 resulted from the mutation. In the presence of GATA4, activation of the ANF promoter driven luciferase reporter in HeLa cells by wild-type MEF2C or L38P-mutant MEF2C L38P) showed significantly diminished synergistic transcriptional activation between L38P-mutant MEF2C and GATA4. Three independent transfection experiments were done in triplicate for each expression plasmid, and mean and standard deviations are given. * indicates t = 9.37232, p = 0.00072, when compared with the wild-type counterpart.