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. 2017 Sep 30;14(12):1276–1283. doi: 10.7150/ijms.20479

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Activation of L1 promoted cell migration and cell survival. To verify the role of L1 in cell migration, the undersurface of transwell membranes was coated with L1Ab. Relative number of cells transmigrating through the membrane were determined by staining cells on the undersurface of the transwell membrane followed by cell lysis and measurement of absorbance value. Optical density measurements of the dye were directly proportional to numbers of migrated cells. A. Cell migration was significantly enhanced in L1-CHO cells after treatment with L1Ab (L1-CHO-L1Ab) versus L1Ab-treated non-transfected CHO cells (CHO-L1Ab). Photomicrographs illustrate the greater density of migrated L1-CHO cells treated with L1Ab (L1-CHO-L1Ab) on the undersurface of the membrane. B. Quantitative measurements from Figure 3A. C. To investigate the role of L1 in cell survival, MTT analysis was performed. Cell survival was significantly enhanced in the L1-CHO cells versus CHO cells. *: p<0.05, by Student's test.