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. 2017 Sep 30;14(12):1276–1283. doi: 10.7150/ijms.20479

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Inhibition of sialylation and fucosylation decreased cell migration and cell survival. A. Cell migration assay was performed in L1Ab-treated L1-CHO cells treated with Soyasaponin I (STI; 2.72mg/ml, 5.44mg/ml) or Tunicamycin (FUTI; 1μg/ml, 5μg/ml, 25μg/ml, 50μg/ml) versus L1-CHO. Cell migration was significantly inhibited after treatment with Soyasaponin I or Tunicamycin. B. MTT analysis of L1-CHO performed after treatment with Soyasaponin I (STI; 2.72mg/ml, 3.4mg/ml, 4.08mg/ml) or Tunicamycin (FUTI; 25μg/ml, 50μg/ml, 100μg/ml) showed a significant decrease of cell survival. C. Cell migration assay was performed in L1Ab-treated L1-CHO cells treated with Soyasaponin I (STI; 2.72mg/ml) and Tunicamycin (FUTI; 25μg/ml) together versus L1-CHO. Cell migration was significantly inhibited after treatment with Soyasaponin I and Tunicamycin together. D. MTT analysis of L1-CHO performed after treatment with Soyasaponin I (STI; 4.08mg/ml) and Tunicamycin (FUTI; 100μg/ml) together showed a significant decrease of cell survival. *: p<0.05; **: p<0.01, by Student's test.