Table 1.
Genotyped SNPs and the P values of their association with BCR in patients with localized prostate cancer treated with RP
| Gene | SNP ID | Chromosome | Position | Possible Functional Effects | Log-rank P | ||
|---|---|---|---|---|---|---|---|
| Additive | Dominant | Recessive | |||||
| TACSTD2 | rs14008 | 1 | 59042181 | Missense (conservative); Splicing regulation | 0.809 | 0.811 | 0.909 |
| PROM1 | rs6449209 | 4 | 15982166 | Splicing site | 0.924 | 0.932 | 0.803 |
| PROM1 | rs2078622 | 4 | 16037352 | Splicing site | 0.072 | 0.045 | ‒ |
| ITGA2 | rs1062535 | 5 | 52351413 | Sense/synonymous; Splicing regulation | 0.279 | 0.642 | 0.101 |
| ITGA2 | rs1801106 | 5 | 52358757 | Splicing site | 0.646 | 0.646 | ‒ |
| POU5F1 | rs2394882 | 6 | 31132649 | Splicing site | 0.012 | 0.184 | 0.003 |
| EZH2 | rs2302427 | 7 | 148525904 | Missense (conservative) | 0.321 | 0.160 | 0.555 |
| PSCA | rs2294008 | 8 | 143761931 | Missense (conservative); Splicing regulation | 0.181 | 0.217 | 0.344 |
| PSCA | rs3736001 | 8 | 143762807 | Missense (conservative); Splicing regulation | 0.057 | 0.090 | 0.158 |
| CD44 | rs1071695 | 11 | 35201842 | Sense/synonymous; Splicing regulation | 0.905 | 0.934 | 0.656 |
Abbreviations: SNP, single nucleotide polymorphism; BCR, biochemical recurrence; RP, radical prostatectomy.
‒, not calculated due to insufficient numbers.
P < 0.05 are in boldface.