Table 3.

Cumulative Incidence of Organ Toxicities and Late Effects (occurring at least one year after HCT, reported in ≥3% of patients)

Organ Toxicities and Late Effects	Cumulative incidence* % (95% CI)
Growth hormone deficiency / growth disturbance	3-years	6 (4–7)
	5-years	11 (9–14)
	10-years	23 (19–28)
Cataracts	3-years	3 (2–5)
	5-years	10 (7–12)
	10-years	18 (15–22)
Hypothyroidism	3-years	5 (3–7)
	5-years	8 (6–10)
	10-years	13 (10–16)
Gonadal dysfunction / infertility requiring hormone replacement	3- and 5-years	0 (0–1)
	10-years	3 (2–5)
Stroke / seizure	3-years	3 (1–4)
	5-years	3 (2–4)
	8-years**	3 (2–5)
New malignancy	3-years	0
	5-years	1 (0–1)
	10-years	3 (1–5)

^*Death as competing risk. Patients censored at relapse or 2^nd HCT.

^**No events reported after 8 years.