Table 4.
Multivariable Analysis of Risk for Organ Toxicities and Late Effects (occurring at least one year after HCT, reported in ≥3% of patients)
| Parameter | Category | N | Hazard Ratio (95% CI) | P-value |
|---|---|---|---|---|
|
| ||||
| Cataracts | ||||
| Age at HCT | <1 year old | 146 | 1.00 | 0.027* |
| 1–1.99 year old | 218 | 1.06 (0.52–2.14) | 0.88 | |
| 2–2.99 year old | 204 | 1.95 (1.02–3.74) | 0.044 | |
| TBI | No | 324 | 1.00 | <0.0001* |
| Yes | 244 | 17.20 (7.44–39.75) | <0.0001 | |
|
| ||||
| Gonadal dysfunction/infertility | ||||
| Age at HCT | <1 year old | 147 | 1.00 | 0.041* |
| 1–1.99 year old | 220 | 0.60 (0.15–2.41) | 0.47 | |
| 2–2.99 year old | 204 | 2.36 (0.76–7.33) | 0.14 | |
| Sex | Male | 326 | 1.00 | 0.0019 |
| Female | 245 | 7.03 (2.06–24.01) | 0.0019 | |
|
| ||||
| GH deficiency/growth disturbance | ||||
| Donor/stem cell source | HLA-identical sibling | 125 | 1.00 | 0.0025* |
| Other related | 29 | 0.31 (0.04–2.41) | 0.2627 | |
| Unrelated donor (BM or PB) | 174 | 2.91 (1.51–5.62) | 0.0014 | |
| UCB (BM or PB) | 231 | 2.23 (1.11–4.49) | 0.024 | |
| TBI | No | 339 | 1.00 | <0.0001* |
| Yes | 220 | 3.51 (2.22–5.54) | <0.0001 | |
|
| ||||
| Hypothyroidism | ||||
| TBI | No | 340 | 1.00 | <0.0001* |
| Yes | 223 | 5.28 (2..97–9.40) | <0.0001 | |
*
Overall p-value.
GH indicates growth hormone. UCB indicates umbilical cord blood. BM indicates bone marrow. PB indicates peripheral blood.
Significant predictors are presented. There were no significant predictors of stroke/seizure identified.