Figure 2.

Development of visual acuity as measured by VEPs is normal in Cx3cr1 KO animals. A, Experimental timeline of visual acuity assessment in juvenile and adult mice. Animals were implanted and VEPs recorded in response to grating stimuli of 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, and 0.7 cycle/° as juveniles (P28) and later as adults (P60). B, VEP magnitudes do not vary between Cx3cr1 KO animals (magenta) and WT animals (black) as juveniles (solid lines) or adults (dashed lines), including difficult-to-detect spatial frequencies, which yield VEP magnitudes greater than noise (gray bar; n = 8 WT, 7 KO animals). C, Experimental timeline of visual acuity development following eye opening. VEPs were recorded every other day from P21 to P31 across four spatial frequencies (0.05, 0.2, 0.5, and 0.7 cycle/°) with a uniquely oriented (separated by 30° to prevent response potentiation; Cooke and Bear, 2010). D, There is no detectable difference between KO and WT mice at any of the four spatial frequencies tested. In both genotypes, there is a gradual increase in VEP magnitude as the animal matures (n = 14 WT, 17 KO animals).