Table 3.
Lethal phase of the CaMKIIstopw+ mutanta
| Phase | % total mortality |
|
|---|---|---|
| CaMKIIstopw+/+ × CaMKIIstopw+/+ (%) | CaMKIIWTw+/+ × CaMKIIWTw+/+ (%) | |
| Embryo to hatching | 2.9 | 1.7 |
| Hatching to pupation | 16.1 | 3.6 |
| Pupation to adult | 10.1 | 2.0 |
| Total death | 29.1 | 7.3 |
aProgression through development was assessed for the CaMKIIstopw+ null and control CaMKIIWTw+ strains. CaMKII null animals die in both the larval and pupal stages. Death rate in the null strain is consistent with complete preadult lethality for homozygous mutant animals. Collections were done from 16 plates per genotype. N = 1965 fertilized eggs for CaMKIIstopw+ null and 694 for the control CaMKIIWTw+ strain. Full lethality was also observed with an independent allele of CaMKIIstopw+ and in transheterozygotes of the two alleles (data not shown).